Kaposi Sarcoma (classic type-genital lesion)

Diagnosis: Kaposi Sarcoma (classic type-genital lesion)

Keratotic papule on coronal sulcus and small papule on penile shaft.

Clinical Presentation

Keratotic papule on coronal sulcus and small papule on penile shaft.

Clinical History

Submitted by Alaa Saad. Originally posted October 11, 2010.

Treatment

See case discussion.

Differential Diagnosis

• Bacillary angiomatosis • Pyogenic granuloma • Angiosarcoma • Hemangioma • Dermatofibroma • Melanoma • Stasis dermatitis

Key Learnings

• Caused by HHV-8 (Human Herpesvirus 8) in all variants • Four types: classic (elderly Mediterranean men), endemic (sub-Saharan Africa), iatrogenic (immunosuppression), epidemic (HIV/AIDS) • HIV-associated KS: dramatically decreased with effective ART • Patch → plaque → nodular stage progression • Classic KS: indolent course, lower extremity predominance • Histology: spindle cell proliferation with slit-like vascular channels, PAS+ eosinophilic globules

Tags: kaposi, sarcoma, classic, type, genital, lesion, alaa saad