BCC histopathology

Diagnosis: BCC histopathology

Case submitted by dermRounds Dermatology Network to the dermRounds community.

Clinical Presentation

Clinical photograph(s) submitted for peer review and discussion.

Clinical History

Submitted by dermRounds Dermatology Network. Originally posted June 27, 2008.

Treatment

See case discussion.

Differential Diagnosis

• Squamous cell carcinoma • Amelanotic melanoma • Intradermal nevus • Sebaceous hyperplasia • Trichoepithelioma

Key Learnings

• Most common human cancer — accounts for ~80% of non-melanoma skin cancers • Locally destructive but rarely metastasizes (<0.1%) • Classic dermoscopy: arborizing vessels, blue-gray ovoid nests, leaf-like structures • Subtypes: nodular (most common), superficial, morpheaform/infiltrative (highest recurrence) • Hedgehog pathway (PTCH1) is central to pathogenesis

Tags: bcc, histopathology, dermrounds dermatology network