B Cell Lymphoma

Diagnosis: B Cell Lymphoma

fixed inguinal lymphadenopathy

Clinical Presentation

fixed inguinal lymphadenopathy

Clinical History

Submitted by Kiersten Rickenbach. Originally posted May 17, 2009.

Treatment

See case discussion.

Differential Diagnosis

• Squamous cell carcinoma • Amelanotic melanoma • Intradermal nevus • Sebaceous hyperplasia • Trichoepithelioma • Merkel cell carcinoma • Dermatofibroma

Key Learnings

• Most common human cancer — accounts for ~80% of non-melanoma skin cancers • Locally destructive but rarely metastasizes (<0.1%) • Classic dermoscopy: arborizing vessels, blue-gray ovoid nests, leaf-like structures, spoke-wheel structures • Subtypes: nodular (most common), superficial, morpheaform/infiltrative (highest recurrence), pigmented • Gorlin syndrome (PTCH1 mutation): multiple BCCs, odontogenic keratocysts, skeletal anomalies • Hedgehog pathway inhibitors (vismodegib, sonidegib) for advanced/inoperable BCC

Tags: cell, lymphoma, kiersten rickenbach