Collodion Baby

Diagnosis: Collodion Baby

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Clinical Presentation

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Clinical History

Submitted by Mohamed Abdulkhader Emzaeka. Originally posted January 13, 2012.

Treatment

See case discussion.

Differential Diagnosis

• Harlequin ichthyosis • Lamellar ichthyosis • Congenital ichthyosiform erythroderma • Gaucher disease type 2 • Self-healing collodion baby

Key Learnings

• Born encased in a tight, shiny, translucent membrane (collodion membrane) • A phenotype, not a diagnosis — most commonly evolves into lamellar ichthyosis or congenital ichthyosiform erythroderma • ~10% are "self-healing" collodion babies with normal underlying skin • Neonatal complications: ectropion, eclabion, restricted breathing, feeding difficulties • Risk of fluid loss, temperature instability, and sepsis — NICU care required • Membrane typically sheds within 2-4 weeks

Tags: collodion, baby, mohamed abdulkhader emzaeka